›› 2011, Vol. 23 ›› Issue (2): 123-127.doi: 10.3969/j.issn.1004-616x.2011.02.010

• 论著 • Previous Articles     Next Articles

Expression and clinical　 significance of combined　 detection on Syk and nm23H1 proteins in colorectal cancer

ZHANG Jun1，SUN Guo-gui1，FU Zhan-zhao2，WANG Ya-di3,*，XU Hong4，GU Tao2   

  1. 1. Department of Radiotherapy, The Fourth Hospital of Hebei Medical University, Shijiazhuang 050011, Hebei; 2. Department of Oncology, The First Hospital of Qinhuangdao, Qinhuangdao 06600, Hebei; 3. Department of Radiotherapy, The Military General Hospital of Beijing PLA, Beijing 100700; 4. Department of Medical Research Center, Hebei United University, Tangshan 063000, Hebei, China
  • Received:2010-12-27 Revised:2011-01-06 Online:2011-03-30 Published:2011-03-30
  • Contact: WANG Ya-di

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Abstract: To investigate the expression of Spleen tyosine kinase (Syk) and of metastasis suppressor gene (nm23H1) and to determine the relationship between their expressions and clinico-pathological features有 and biological behavior in colorectal cancer. METHODS： Immunohistochemistry (SP) was used to detect the expressions of Syk and nm23H1 in 60 colorectal cancer tissues and normal colorectal cancer mucosa (5 cm distant to the margin of colorectal cancer and no microscopic cancer infiltration). RESULTS： The positive rates of Syk and nm23H1 proteins were 31.7%， 53.3%, respectively, in colorectal carcinoma tissues but 96.7%，93.3%, respectively, in normal tissues (P＜0.05). There was a significant difference in Syk and nm23H1 protein expression between lymph node metastasis， depths of invasion and Dukes stage(P＜0.05)，but not with sex， age，tumor size，lesion site and differentiation degree(P＞0.05). CONCLUSION： The expressions of Syk and nm23H1 proteins were lower in colorectal cancer tissues， suggesting that the Syk and nm23H1 genes may be closely associated with oncogenesis and malignant degree. Detection of Syk and nm23H1 may be used for early diagnosis， clinical therapy and prognosis of colorectal carcinoma.

Key words: Syk, nm23H1, colorectal cancer, immunohistochemistry